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- Rapid changes in ventilation cause changes in pH due to shifting CO2 concentrations.
- When alveolar ventilation changes, the partial pressure of CO2 in the arteries changes.
- Since CO2 is lipid soluble, it can easily cross the lipid bilayer and Cross the membranes.
- The change in arterial pH is picked by central & peripheral chemo receptors in the arteries.
- This information is sent to the respiratory centers in the medulla.
- Nerve signals are sent to the respiratory muscles to respond