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Aphthous Ulcer

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What is an aphthous ulcer?

An aphthous ulcer is an ulcer that forms on the mucous membranes. They are also called aphthae, aphthosis, aphthous stomatitis and canker sores.

An aphthous ulcer is typically a recurrent round or oval sore or ulcer inside the mouth on an area where the skin is not tightly bound to the underlying bone, such as on the inside of the lips and cheeks or underneath the tongue. Aphthous ulcers can also affect the genitalia in males and females.

Recurrent aphthous ulcers are mostly a minor nuisance, but they are associated with significant health problems in some people.

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Who is at risk of aphthous ulcer?

Anyone can get an aphthous ulcer; 20% of the population have one or more, at least occasionally. They usually first appear in childhood or adolescence, and more commonly affect females than males.

Interestingly, smoking may be protective against aphthae, even though smoking make many oral and skin conditions worse.


What is the differential diagnosis of aphthous ulcer?

Other causes of mouth ulcer should be considered, including:

  • Herpes simplex
  • Herpangina
  • Erythema multiforme
  • Fixed drug eruption.


What are the signs and symptoms of aphthous ulcer?

Recurrent aphthous ulcer usually begins as a round yellowish elevated spot surrounded by a red halo. This then breaks down into a punched-out ulcer, which is covered with a loosely attached white, yellow or greyish membrane. Surrounding tissue is healthy and unaffected. The ulcer can be painful, particularly if irritated by movement or eating certain types of food such as citrus fruit.

People may experience a single ulcer or multiple ulcers. Multiple ulcers tend to be widely distributed throughout a person’s mouth.

Aphthous ulcer is classified into three types.

  • Recurrent minor aphthous ulcer (80%). This is less than 5 mm in diameter and heals within 1–2 weeks.
  • Major aphthous ulcer, which is large (often more than 10 mm) and takes weeks or months to heal and leaves a scar.
  • Herpetiform ulcers, which are multiple pinpoint ulcers that heal within a month. These are most commonly on the tongue.

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What tests should be done in aphthous ulceration?

Most people affected by occasional minor aphthous ulceration do not require tests. They are undertaken if there are recurrent attacks of multiple or severe oral ulcers, or complex aphthosis.

Blood tests may include:

  • Blood count, iron, B12 and folate studies
  • Gluten antibody tests for coeliac disease
  • Faecal calprotectin test for Crohn disease

Swabs for microbiology evaluate the presence of Candida albicans, Herpes simplex virus and Vincent’s organisms.


What is the treatment for aphthous ulcer?

There is no cure for aphthous ulcer. Most recurrent minor aphthous ulcers heal within 1–2 weeks without any treatment. The main goal of treatment is to lessen pain and discomfort, and promote healing.


General measures

  • Protective pastes that form a barrier over the ulcer so that exposure to irritating substances is reduced.
  • Superficial tissue cauterization using silver nitrate stick
  • Local anaesthetics benzocaine and lignocaine (lidocaine) to reduce pain
  • Medicated toothpaste without sodium laureth sulfate
  • Antibacterial mouthwashes to reduce secondary infection.
  • Avoidance of foods that trigger or exacerbate the ulcers.
  • Dietary supplements of vitamins or minerals, if diet is deficient.
  • Reduction in stress


Prescribed medicines for aphthous ulcer

Topical prescription medicines include:

  • Tetracycline suspension as mouthwash
  • Topical corticosteroids as lotions, creams or paste, often triamcinolone in dental paste
  • Calcineurin inhibitors: topical pimecrolimus or tacrolimus.

In severe cases, particularly if there are systemic symptoms, anti-inflammatory oral medications may be considered (off-label use):

  • Tetracycline, e.g. doxycycline 50-100mg daily for 3-6 months or longer.
  • Dapsone
  • Colchicine
  • Systemic steroids
  • Immunosuppressive agents such as azathioprine, methotrexate, ciclosporin
  • Tumour necrosis factor (TNF) antagonists (adalimumab, etanercept, infliximab)
  • Thalidomide.

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